The essential oil has been reported to be one of the Angiotensin I-Converting Enzyme (ACE) inhibitor resources. Moreover, it has been proven against bacterial pathogens that cause infectious diseases. Amomum compactum is one source of essential oil, known as Javanese cardamom is a spice herb commonly used for flavouring food and traditional medicine in Indonesia. However, ACE inhibition activity of A. compactum has not been reported. The purposes of this study were to identify the main constituent of volatile compounds, inhibition activity toward bacteria, and antihypertension potency of A. compactum essential oils. Volatile compounds were investigated using Gas Chromatography-Mass Spectrometry (GC-MS). The antimicrobial activity was observed using the microdilution method toward Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. The antihypertension effect was studied using an ACE inhibition assay. The result showed that eucalyptol was a primary compound of A. compactum fruit either in Banjar (BJR) and Bogor (BGR) essential oils with the value of 62.22% and 66.23%, respectively. Both BJR and BGR are more active to inhibit gram-positive bacteria (B. subtilis) with MIC values of 1 mg/mL. Meanwhile, the BJR exhibited a higher inhibitory activity effect toward ACE compared to BGR with the value of IC50 64.86 ± 0.57 μg/mL. These findings suggest that A. compactum essential oil can be the potential to lead to the treatment of hypertension as an ACE inhibitor and antibacterial agent.
Supplementary information: The online version contains supplementary material available at 10.1007/s12088-023-01080-x.
Keywords: ACE inhibition; Amomum compactum; Antibacterial; Antihypertensive; Essential oils.
© Association of Microbiologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.