Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis

Shengju Chen; Kaixiang Zhou; Huayu Shang; Mingyang Du; Linfeng Wu; Yu Chen

doi:10.3389/fendo.2023.1216962

Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis

Front Endocrinol (Lausanne). 2023 Sep 13:14:1216962. doi: 10.3389/fendo.2023.1216962. eCollection 2023.

Authors

Shengju Chen¹, Kaixiang Zhou², Huayu Shang³, Mingyang Du⁴, Linfeng Wu⁴, Yu Chen⁴

Affiliations

¹ School of Physical Education, Liaoning Normal University, Dalian, China.
² Sports Health College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
⁴ College of Physical Education, Chongqing University, Chongqing, China.

Abstract

Objective: To determine the impacts of concurrent aerobic and resistance training on vascular structure (IMT) and function (PWV, FMD, NMD) in type 2 diabetes (T2D).

Methods: The electronic databases PubMed, Web of Science Core Collection, Cochrane Library, Embase, Scopus, CINAHL, and SPORTDiscus were systematically searched for articles on "type 2 diabetes" and "concurrent training" published from inception to August 2, 2022. We included randomized controlled trials that examined the effects of concurrent training versus passive controls on IMT, PWV, FMD and NMD in T2D.

Results: Ten studies were eligible, including a total of 361 participants. For IMT, concurrent training showed a slight decrease by 0.05 mm (95% CI -0.11 to 0.01, p > 0.05). concurrent training induced an overall significant improvement in FMD by 1.47% (95% CI 0.15 to 2.79, p < 0.05) and PWV by 0.66 m/s (95% CI -0.89 to -0.43, p < 0.01) in type 2 diabetics. However, concurrent training seemed to exaggerate the impaired NMD (WMD = -2.30%, 95% CI -4.02 to -0.58, p < 0.05).

Conclusions: Concurrent training is an effective method to improve endothelial function and artery stiffness in T2D. However, within 24 weeks concurrent training exacerbates vascular smooth muscle dysfunction. More research is needed to explore whether longer and/or higher-intensity concurrent training interventions could enhance the vascular structure and smooth muscle function in this population.

Systematic review registration: www.crd.york.ac.uk/PROSPERO/, identifier CRD42022350604.

Keywords: aerobic and resistance training; concurrent training; type 2 diabetes; vascular function; vascular structure.

Publication types

Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / therapy
Exercise / physiology
Humans
Muscle, Smooth, Vascular
Resistance Training* / methods
Vascular Stiffness* / physiology

Grants and funding

YC was funded by China Postdoctoral Science Foundation (Grant NO. 2021M693736); the Fundamental Research Funds for the Central Universities (Grant NO. 2022CDSKXYTY003). HS was supported by the Natural Science Foundation of Sichuan Province (Grant NO. 2023NSFSC1524).