The Role of Uterine Artery Doppler in the Second and Third Trimesters for Prediction of Preeclampsia and Fetal Growth Restriction Developed as a Consequence of Placental-Mediated Diseases

Adriana Tudor; Liliana Novac; Ioana-Victoria Camen; Maria Magdalena Manolea; Maria-Sidonia Sandulescu; Sidonia Catalina Vrabie; Mircea-Sebastian Serbanescu; Mihail Virgil Boldeanu; Anca-Maria Istrate-Ofiteru; Anda Lorena Dijmarescu

doi:10.12865/CHSJ.49.02.251

The Role of Uterine Artery Doppler in the Second and Third Trimesters for Prediction of Preeclampsia and Fetal Growth Restriction Developed as a Consequence of Placental-Mediated Diseases

Curr Health Sci J. 2023 Apr-Jun;49(2):251-256. doi: 10.12865/CHSJ.49.02.251. Epub 2023 Jun 30.

Authors

Affiliations

¹ Doctoral School, University of Medicine and Pharmacology of Craiova, Romania.
² Obstetrics and Gynecology Department, University of Medicine and Pharmacology of Craiova, Romania.
³ Obstetrics and Gynecology Department, "Filantropia" Hospital, Craiova, Romania.
⁴ Medical Informatics Department, University of Medicine and Pharmacology of Craiova, Romania.
⁵ Immunology Department, University of Medicine and Pharmacy of Craiova, Romania.
⁶ Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania.

Abstract

Placenta-mediated pregnancy disorders represent a disease that includes preeclampsia (PE) and the birth of small for gestational age (SGA) children, these conditions increase the risk of mortality and morbidity both maternal and fetal/neonatal, in the short and long-term.

Methods: The prospective study included 106 patients in whom ultrasound Doppler scans of uterine artery (UtA) were performed in the 2nd trimester between 20.0-23.6 weeks of gestation and the 3rd trimester between 28.0-32.6 weeks of gestation.

Results: In the second trimester, the average of the UtA-PI percentiles was statistically significant (p<0.05) in correlation with PE and SGA, as in the third trimester. Statistically significant (p<0.05) was also the correlation of UtA-PI >95 percentile with the development of PE and SGA. On the other hand, the present notch, in the two trimesters studied, analyzed as a single index, did not present a statistically significant association (p>0.05).

Conclusions: The results of our study showed that UtA-PI Doppler is the best predictor of preeclampsia considering the association of intrauterine growth restriction, as most studies have found.

Keywords: Doppler ultrasonography; PE; SGA; UtA.