Isolation and characterization of Akabane virus Ib substrain and its pathogenesis in sulking mice

Virol Sin. 2023 Dec;38(6):966-970. doi: 10.1016/j.virs.2023.09.006. Epub 2023 Sep 29.

¹ State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, 010070, China.
² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, 010070, China; College of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010080, China.
⁴ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: beeyh@im.ac.cn.
⁵ State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, 010070, China; Inner Mongolia Mengwei Biotech Co. Ltd, Hohhot, 012000, China. Electronic address: wangwei@imu.edu.cn.

Abstract

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Akabane virus sub-lineage genogroup Ib was identified and isolated in China for the first time.
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The suckling mice showed clinical symptoms after intracerebrally infected with LK07 strain.
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Viral antigen was detected in brain of mice infected with LK07 strain via IC, IP and SC routes.