Novel antimicrobial and self-healing dental resin to combat secondary caries and restoration fracture

Shuo Yao; Ludan Qin; Li Ma; Xiaoran Zhang; He Jiang; Jiajia Zhang; Chuanjian Zhou; Junling Wu

doi:10.1016/j.dental.2023.09.009

Novel antimicrobial and self-healing dental resin to combat secondary caries and restoration fracture

Dent Mater. 2023 Nov;39(11):1040-1050. doi: 10.1016/j.dental.2023.09.009. Epub 2023 Sep 29.

Authors

Shuo Yao¹, Ludan Qin¹, Li Ma¹, Xiaoran Zhang¹, He Jiang¹, Jiajia Zhang¹, Chuanjian Zhou², Junling Wu³

Affiliations

¹ Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China.
² Research Institute of Polymer Materials, School of Materials Science and Engineering, Shandong University, Jinan 250061, China.
³ Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China. Electronic address: doctorwujunling@163.com.

PMID: 37777432
DOI: 10.1016/j.dental.2023.09.009

Abstract

Objective: Dental resin composites have been the most popular materials for repairing tooth decay in recent years. However, secondary caries and bulk fracture are the major hurdles that affect the lifetime of dental resin composites. This current study synthesized a novel antimicrobial and self-healing dental resin containing nanoparticle-modified self-healing microcapsules to combat secondary caries and restoration fracture.

Methods: Multifunctional dental resins containing 0-20% nanoparticle-modified self-healing microcapsules were prepared. The water contact angle, antimicrobial properties, mechanical properties, cell toxicity, and self-healing capability of the dental resins were tested.

Results: A novel multifunctional dental resin was synthesized. When the microcapsule mass fraction was 10%, the resin presented a strong bacteriostasis rate (80.3%) and excellent self-healing efficiency (66.1%), while the hydrophilicity, mechanical properties, and cell toxicity were not affected.

Significance: The novel antimicrobial self-healing dental resin is a promising candidate for use in clinical practice, which provides a simple and highly efficient strategy to combat secondary caries and restoration fracture. This novel dental resin also gives the inspiration to prolong the service life of dental restorations.

Keywords: Antimicrobial; Dental resin; Mechanical property; Microcapsules; Nanoparticles; Self-healing.