Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway

Asma B Omer; Hisham N Altayb; Fahad A Al-Abbasi; Gaurav Gupta; Mohammed Muqtader Ahmed; Amira M Alghamdi; Sami I Alzarea; Nadeem Sayyed; Muhammad Shahid Nadeem; Imran Kazmi

doi:10.1016/j.ijbiomac.2023.127127

Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway

Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127127. doi: 10.1016/j.ijbiomac.2023.127127. Epub 2023 Sep 28.

Authors

Affiliations

¹ Department of Basic Health Sciences, Foundation Year for the Health Colleges, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia. Electronic address: abalfaki@pnu.edu.sa.
² Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: hdemmahom@kau.edu.sa.
³ Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: fabbasi@kau.edu.sa.
⁴ Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Jaipur, India. Electronic address: drgaurav.gupta@mygyanvihar.com.
⁵ Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia. Electronic address: mo.ahmed@psau.edu.sa.
⁶ Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: Amaalghamdi1@kau.edu.sa.
⁷ Department of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Sakaka 72341, Saudi Arabia. Electronic address: samisz@ju.edu.sa.
⁸ School of Pharmacy, Glocal University, Saharanpur 247121, India.
⁹ Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: mhalim@kau.edu.sa.
¹⁰ Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: ikazmi@kau.edu.sa.

PMID: 37776926
DOI: 10.1016/j.ijbiomac.2023.127127

Abstract

Acemannan, the main polysaccharide in Aloe vera, is a -(1, 4)-acetylated polymannose. According to numerous research findings, acemannan is a viable alternative for the treatment of pathological disorders. Streptozotocin (STZ, 60 mg/kg) administered intraperitoneally caused type 2 diabetes in rats. The current study sought to determine the anti-diabetic efficacy of acemannan (25 and 50 mg/kg) in STZ-injected rats. Different biochemical parameters including HbA1C, glucose and serum insulin, lipid profile, inflammatory markers, antioxidant, oxidative balance, liver function test, glycogen and creatinine, and caspase-3 were evaluated. In addition, a molecular docking study was performed to estimate acemannan's binding affinity to inflammatory markers. Acemannan may be a potent anti-diabetic agent for the treatment of diabetic patients, which will aid in future research into alternative diabetes medications.

Keywords: Acemannan; Apoptosis; Docking study; Polysaccharide; Streptozotocin.

MeSH terms

Animals
Apoptosis
Cytokines*
Diabetes Mellitus, Type 2* / drug therapy
Glucose
Humans
Molecular Docking Simulation
Oxidative Stress
Rats
Streptozocin

Substances

acemannan
Cytokines
Streptozocin
Glucose