Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)

Wendy Hsiao; Yimei Li; Kelly Getz; Lusha Cao; Edward Krause; Mark Ramos; Judy Lee; Maria Monica Gramatges; Karen R Rabin; Michael E Scheurer; Richard Aplenc; Michelle Denburg; Tamara P Miller

doi:10.1002/pbc.30696

Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)

Pediatr Blood Cancer. 2023 Dec;70(12):e30696. doi: 10.1002/pbc.30696. Epub 2023 Sep 30.

Authors

Wendy Hsiao^{1

2}, Yimei Li^{3

4}, Kelly Getz^{3

4

5}, Lusha Cao⁶, Edward Krause⁶, Mark Ramos⁶, Judy Lee⁷, Maria Monica Gramatges^{8

9}, Karen R Rabin^{8

9}, Michael E Scheurer^{8

9}, Richard Aplenc^{3

5}, Michelle Denburg^{2

4

5}, Tamara P Miller^{7

10}

Affiliations

¹ Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, California, USA.
² Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
³ Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁴ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁵ Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶ Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁷ Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
⁸ Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA.
⁹ Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
¹⁰ Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.

Abstract

Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.

Keywords: acute kidney disease; acute kidney injury; acute lymphoblastic leukemia; acute myeloid leukemia; chronic kidney disease.

MeSH terms

Acute Kidney Injury* / chemically induced
Acute Kidney Injury* / epidemiology
Child
Electronics
Hospital Mortality
Humans
Kidney
Leukemia, Myeloid, Acute* / complications
Leukemia, Myeloid, Acute* / therapy
Renal Insufficiency, Chronic* / epidemiology
Retrospective Studies
Risk Factors

Abstract

MeSH terms

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