Regulatory architecture of cell identity genes and housekeeping genes

Alessandra Dall'Agnese; Richard Young

doi:10.1016/j.tcb.2023.08.007

Regulatory architecture of cell identity genes and housekeeping genes

Trends Cell Biol. 2023 Dec;33(12):1010-1013. doi: 10.1016/j.tcb.2023.08.007. Epub 2023 Sep 27.

Authors

Alessandra Dall'Agnese¹, Richard Young²

Affiliations

¹ Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
² Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: young@wi.mit.edu.

PMID: 37775397
PMCID: PMC10873096 (available on 2024-12-01)
DOI: 10.1016/j.tcb.2023.08.007

Abstract

Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.

Keywords: cell identity; condensate; gene regulatory elements; housekeeping; transcription.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Enhancer Elements, Genetic* / genetics
Gene Expression Regulation / genetics
Genes, Essential* / genetics
Humans
Promoter Regions, Genetic

Abstract

Publication types

MeSH terms

Grants and funding