Innovations in Small-Animal PET Instrumentation

Adrienne L Lehnert; Robert S Miyaoka

doi:10.1016/j.cpet.2023.09.002

Innovations in Small-Animal PET Instrumentation

PET Clin. 2024 Jan;19(1):59-67. doi: 10.1016/j.cpet.2023.09.002. Epub 2023 Sep 27.

Authors

Adrienne L Lehnert¹, Robert S Miyaoka²

Affiliations

¹ Department of Radiology, University of Washington, 1959 Northeast Pacific Street, UW Box 356043, Seattle, WA, USA. Electronic address: alehnert@uw.edu.
² Department of Radiology, University of Washington, 1959 Northeast Pacific Street, UW Box 356043, Seattle, WA, USA.

PMID: 37775371
DOI: 10.1016/j.cpet.2023.09.002

Abstract

Biomedical research has long relied on small-animal studies to elucidate disease process and develop new medical treatments. The introduction of in vivo functional imaging technology, such as PET, has allowed investigators to peer inside their subjects and follow disease progression longitudinally as well as improve understanding of normal biological processes. Recent developments in CRISPR, immuno-PET, and high-resolution in vivo imaging have only increased the importance of small-animal, or preclinical, PET imaging. Other drivers of preclinical PET innovation include new combinations of imaging technologies, such as PET/MR imaging, which require changes to PET hardware.

Keywords: Functional imaging; PET/CT; PET/MR; Preclinical PET; Spatial resolution.

Publication types

Review

MeSH terms

Animals
Disease Progression
Humans
Magnetic Resonance Imaging* / methods
Positron-Emission Tomography* / methods