Serum cytokine profiles in myasthenia gravis with anti-muscle-specific kinase antibodies

Manato Yasuda; Akiyuki Uzawa; Yukiko Ozawa; Yuta Kojima; Yosuke Onishi; Hiroyuki Akamine; Satoshi Kuwabara

doi:10.1016/j.jneuroim.2023.578205

Serum cytokine profiles in myasthenia gravis with anti-muscle-specific kinase antibodies

J Neuroimmunol. 2023 Nov 15:384:578205. doi: 10.1016/j.jneuroim.2023.578205. Epub 2023 Sep 20.

Authors

Manato Yasuda¹, Akiyuki Uzawa², Yukiko Ozawa³, Yuta Kojima⁴, Yosuke Onishi¹, Hiroyuki Akamine¹, Satoshi Kuwabara¹

Affiliations

¹ Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
² Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: auzawa@chiba-u.jp.
³ Department of Neurology, Graduate School of Medicine, Chiba University, Japan; Department of Neurology, Japanese Red Cross Narita Hospital, Japan.
⁴ Department of Neurology, Graduate School of Medicine, Chiba University, Japan; Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

PMID: 37774555
DOI: 10.1016/j.jneuroim.2023.578205

Abstract

This study measured the serum levels of of 15 cytokines in 15 patients with anti-muscle-specific kinase antibody-positive MG (MuSK-MG) using a multiplex suspension array system. Fifteen patients with non-inflammatory neurological diseases served as controls. Compared with controls, patients with MuSK-MG showed higher levels of Th1- (IFN-γ), Th2- (IL-25, IL-31, and IL-33), Th17- (IL-22), Treg-related cytokines (IL-10), and soluble CD40 ligand (sCD40L). Higher serum Th2-related cytokines (IL-25 and IL-31) levels were correlated with less MG Foundation of America (MGFA) class. These suggest that Th2-related cytokines have protective effects, whereas sCD40L and others may facilitate the disease.

Keywords: Anti-muscle-specific kinase antibody; Cytokines; Interleukin; Myasthenia gravis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Humans
Myasthenia Gravis*
Th17 Cells

Substances

Cytokines