Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates

J Virol. 2023 Oct 31;97(10):e0115423. doi: 10.1128/jvi.01154-23. Epub 2023 Sep 29.

Abstract

HIV infection can be effectively treated to prevent the development of AIDS, but it cannot be cured. We have attached poisons to anti-HIV antibodies to kill the infected cells that persist even after years of effective antiviral therapy. Here we show that the killing of infected cells can be markedly enhanced by the addition of soluble forms of the HIV receptor CD4 or by mimics of CD4.

Keywords: CD4 mimetic; HIV cure; HIV envelope; cytotoxic immunoconjugate; gp41 and gp120; human immunodeficiency virus; immunotoxin; soluble CD4.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • CD4 Antigens* / chemistry
  • CD4 Antigens* / immunology
  • CD4 Antigens* / therapeutic use
  • Cell Line
  • Cytotoxins* / chemistry
  • Cytotoxins* / therapeutic use
  • HIV Antibodies* / chemistry
  • HIV Antibodies* / immunology
  • HIV Antibodies* / therapeutic use
  • HIV Infections* / drug therapy
  • HIV Infections* / immunology
  • HIV Infections* / pathology
  • HIV Infections* / virology
  • HIV-1* / drug effects
  • HIV-1* / immunology
  • Humans
  • Immunoconjugates* / chemistry
  • Immunoconjugates* / immunology
  • Immunoconjugates* / therapeutic use
  • Molecular Weight

Substances

  • CD4 Antigens
  • Immunoconjugates
  • recombinant soluble CD4
  • HIV Antibodies
  • Cytotoxins