The quest for cleaner pathways to the production of fuels and chemicals from non-fossil feedstock, efficient transformation of raw materials to value-added chemicals under mild conditions, and control over the activity and selectivity of chemical processes are driving the state-of-the-art approaches to the construction and precise chemical modification of sustainable nanocatalysts. As a burgeoning category of atomically precise noble metal nanoclusters, copper nanoclusters (Cu NCs) benefitting from their exclusive structural architecture, ingenious designability of active sites and high surface-to-volume ratio qualify as potential rationally-designed catalysts. In this Minireview, we present a detailed coverage of the optimal design strategies and controlled synthesis of Cu NC catalysts with a focus on tuning of active sites at the atomic level, the implications of cluster size, shape and structure, the ligands and heteroatom doping on catalytic activity, and reaction scope ranging from chemical catalysis to emerging photocatalysis and electrocatalysis.