Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy

Ling-Ling Wei; Shu-Ting Zhang; Yu Liao; Yue Zhang; Yan Yu; Na Mi

doi:10.5498/wjp.v13.i9.675

Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy

World J Psychiatry. 2023 Sep 19;13(9):675-684. doi: 10.5498/wjp.v13.i9.675.

Authors

Ling-Ling Wei¹, Shu-Ting Zhang¹, Yu Liao¹, Yue Zhang¹, Yan Yu¹, Na Mi²

Affiliations

¹ Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.
² Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China. mina_email@163.com.

Abstract

Background: Spiritual wellbeing emphasizes optimistic and positive attitudes while self-regulating negative emotions when coping with stress. However, there have only been a few small studies of spiritual wellbeing of pancreatic ductal adenocarcinoma (PDAC) patients undergoing chemotherapy. The core factors influencing spiritual wellbeing in this clinical population are still unclear.

Aim: To identify factors influencing spiritual wellbeing among patients with PDAC receiving chemotherapy.

Methods: A total of 143 PDAC patients receiving chemotherapy were enrolled from January to December 2022. Patients completed general information questionnaires including: Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being 12 Item Scale (FACIT-Sp-12), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Zung's Self-rating Anxiety Scale (SAS). Independent sample t-test, one-way analysis of variance, Pearson's correlation analysis, and multiple linear regression analysis were adopted for statistical analyses. P < 0.05 (two-tailed) was considered statistically significant for all tests.

Results: Total spiritual wellbeing (FACIT-Sp-12) score was 32.16 ± 10.06 points, while dimension sub-scores were 10.85 ± 3.76 for faith, 10.55 ± 3.42 for meaning, and 10.76 ± 4.00 for peace. Total spiritual wellbeing score was negatively correlated with SAS score for anxiety and with the symptom domain of EORTC QLC-C30. Conversely, spiritual wellbeing score was positively correlated with global health status and EORTC QLQ-C30 role functioning domain score. Multivariate regression analysis identified educational level, health insurance category, symptom domain, functional role domain, and global health status as significant independent factors influencing spiritual wellbeing among PDAC patients undergoing chemotherapy (R² = 0.502, P < 0.05).

Conclusion: Individualized spiritual support is needed for PDAC patients. Health, daily functioning, emotional, cognitive, and social function status should be taken into account to promote implementation of spirituality in nursing practice.

Keywords: Anxiety; Chemotherapy; Pancreatic ductal adenocarcinoma; Quality of life; Spiritual wellbeing.