Role of histone lactylation interference RNA m6A modification and immune microenvironment homeostasis in pulmonary arterial hypertension

Shuai-Shuai Zhao; Jinlong Liu; Qi-Cai Wu; Xue-Liang Zhou

doi:10.3389/fcell.2023.1268646

Role of histone lactylation interference RNA m⁶A modification and immune microenvironment homeostasis in pulmonary arterial hypertension

Front Cell Dev Biol. 2023 Sep 12:11:1268646. doi: 10.3389/fcell.2023.1268646. eCollection 2023.

Authors

Shuai-Shuai Zhao¹, Jinlong Liu², Qi-Cai Wu¹, Xue-Liang Zhou¹

Affiliations

¹ Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
² Institute of Translational Medicine, Shanghai University, Shanghai, China.

Abstract

Pulmonary arterial hypertension (PAH) is a severe disease resulting from progressive increases in pulmonary vascular resistance and pulmonary vascular remodeling, ultimately leading to right ventricular failure and even death. Hypoxia, inflammation, immune reactions, and epigenetic modifications all play significant contributory roles in the mechanism of PAH. Increasingly, epigenetic changes and their modifying factors involved in reprogramming through regulation of methylation or the immune microenvironment have been identified. Among them, histone lactylation is a new post-translational modification (PTM), which provides a novel visual angle on the functional mechanism of lactate and provides a promising diagnosis and treatment method for PAH. This review detailed introduces the function of lactate as an important molecule in PAH, and the effects of lactylation on N6-methyladenosine (m⁶A) and immune cells. It provides a new perspective to further explore the development of lactate regulation of pulmonary hypertension through histone lactylation modification.

Keywords: epigenetic modifications; histone lactylation; immune microenvironment; m6A; post-translational modification; pulmonary arterial hypertension.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Natural Science Foundation of China (Nos 81970199, 82160082, and 82360060), the Natural Science Foundation of Jiangxi Province (Nos 20232ACB206003 and 20202BAB206006).