Allogeneic hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia with intestinal Behçet's disease: A case report

Int J Rheum Dis. 2024 Jan;27(1):e14882. doi: 10.1111/1756-185X.14882. Epub 2023 Sep 28.

Abstract

Behçet's disease (BD) is a rare condition that is seldom associated with hematological malignancies. In this case report, we present the unique case of a 7-year-old girl diagnosed with juvenile myelomonocytic leukemia (JMML) and intestinal BD. The patient received allogeneic hematopoietic stem cell transplantation (allo-HSCT), which resulted in complete remission of both JMML and BD. Our findings suggest that allo-HSCT may be a feasible treatment option for JMML patients with coexisting BD, and holds promise for achieving remission of both illnesses. However, further clinical investigations are needed to validate these findings.

Keywords: Behçet's disease; allogeneic hematopoietic stem cell transplantation; autoimmunity; juvenile myelomonocytic leukemia; myeloid malignancy.

Publication types

  • Case Reports

MeSH terms

  • Behcet Syndrome* / complications
  • Behcet Syndrome* / diagnosis
  • Behcet Syndrome* / therapy
  • Child
  • Female
  • Hematopoietic Stem Cell Transplantation* / methods
  • Humans
  • Leukemia, Myelomonocytic, Juvenile* / complications
  • Leukemia, Myelomonocytic, Juvenile* / diagnosis
  • Leukemia, Myelomonocytic, Juvenile* / therapy
  • Pathologic Complete Response