Revolutionizing treatment for triple-negative breast cancer: Harnessing the power of exosomal miRNAs for targeted therapy

Abduladheem Turki Jalil; Muhanad Tareq Jehad; Lubna R Al-Ameer; Anwar Qasim Khallawi; Israa M Essa; Muna S Merza; Rahman S Zabibah; Farah Al-Hili

doi:10.1016/j.prp.2023.154825

Revolutionizing treatment for triple-negative breast cancer: Harnessing the power of exosomal miRNAs for targeted therapy

Pathol Res Pract. 2023 Oct:250:154825. doi: 10.1016/j.prp.2023.154825. Epub 2023 Sep 16.

Authors

Abduladheem Turki Jalil¹, Muhanad Tareq Jehad², Lubna R Al-Ameer³, Anwar Qasim Khallawi⁴, Israa M Essa⁵, Muna S Merza⁶, Rahman S Zabibah⁷, Farah Al-Hili⁸

Affiliations

¹ College of Medicine, University of Thi-Qar, Al-Nasiriyah, Thi-Qar, Iraq. Electronic address: abedalazeem799@gmail.com.
² College of Dentistry, Al-Esraa University, Baghdad, Iraq.
³ College of Pharmacy, Al-Zahraa University for Women, Iraq.
⁴ College of Health and Medical Technologies, Medical Laboratory Department, National University of Science and Technology, Dhi Qar, Iraq.
⁵ University of Basrah, College of Veterinary Medicine, Department of Veterinary Parasitology, Iraq.
⁶ Prosthetic Dental Techniques Department, Al-Mustaqbal, University College, Hillah, Babylon, Iraq.
⁷ Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
⁸ Medical technical college, Al-Farahidi University, Baghdad, Iraq.

PMID: 37769396
DOI: 10.1016/j.prp.2023.154825

Abstract

Triple-negative breast cancer (TNBC) represents a challenging and aggressive form of breast cancer associated with limited treatment options and poor prognosis. Although chemotherapy is a primary therapeutic approach, drug resistance often hinders treatment success. However, the expanding knowledge of TNBC subtypes and molecular biology has paved the way for targeted therapies. Notably, exosomes (extracellular vesicles) have emerged as crucial carriers of tumorigenic factors involved in oncogenesis and drug resistance, facilitating cell-to-cell communication and offering potential as self-delivery systems. Among the cargo carried by exosomes, microRNAs (miRNAs) have gained attention due to their ability to mediate epigenetic changes in recipient cells upon transfer. Research has confirmed dysregulation of exosomal miRNAs in breast cancer cells compared to healthy cells, establishing them as promising biomarkers for cancer diagnosis and prognosis. In this comprehensive review, we summarize the latest research findings that underscore the diagnostic and prognostic significance of exosomal miRNAs in TNBC treatment. Furthermore, we explore contemporary therapeutic approaches utilizing these exosomal miRNAs for the benefit of TNBC patients, shedding light on potential breakthroughs in TNBC management.

Keywords: Exosome; MiRNA; Therapy; Triple negative breast cancer.

Publication types

Review