Chronic Pallidal Local Field Potentials Are Associated With Dystonic Symptoms in Children

Mark Ebden; Lior M Elkaim; Sara Breitbart; Han Yan; Nebras Warsi; MyLoi Huynh; Karim Mithani; Flavia Venetucci Gouveia; Alfonso Fasano; George M Ibrahim; Carolina Gorodetsky

doi:10.1016/j.neurom.2023.08.003

Chronic Pallidal Local Field Potentials Are Associated With Dystonic Symptoms in Children

Neuromodulation. 2024 Apr;27(3):551-556. doi: 10.1016/j.neurom.2023.08.003. Epub 2023 Sep 26.

Authors

Affiliations

¹ Neurosciences and Mental Health Program, the Hospital for Sick Children, Toronto, Ontario, Canada.
² Division of Neurology and Neurosurgery, McGill University, McGill University Health Centre, Montreal, Quebec, Canada.
³ Division of Neurosurgery, the Hospital for Sick Children, Toronto, Ontario, Canada.
⁴ Division of Neurosurgery, the Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
⁵ Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
⁶ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application, Toronto, Ontario, Canada.
⁷ Division of Neurosurgery, the Hospital for Sick Children, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
⁸ Division of Neurology, the Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. Electronic address: carolina.gorodetsky@sickkids.ca.

PMID: 37768258
DOI: 10.1016/j.neurom.2023.08.003

Abstract

Background: Novel deep brain stimulation devices can record local field potentials (LFPs), which represent the synchronous synaptic activity of neuronal populations. The clinical relevance of LFPs in patients with dystonia remains unclear.

Objectives: We sought to determine whether chronic LFPs recorded from the globus pallidus internus (GPi) were associated with symptoms of dystonia in children.

Materials and methods: Ten patients with heterogeneous forms of dystonia (genetic and acquired) were implanted with neurostimulators that recorded LFP spectral snapshots. Spectra were compared across parent-reported asymptomatic and symptomatic periods, with daily narrowband data superimposed in 24 one-hour bins.

Results: Spectral power increased during periods of registered dystonic symptoms: mean increase = 102%, CI: (76.7, 132). Circadian rhythms within the LFP narrowband time series correlated with dystonic symptoms: for delta/theta-waves, correlation = 0.33, CI: (0.18, 0.47) and for alpha waves, correlation = 0.27, CI: (0.14, 0.40).

Conclusions: LFP spectra recorded in the GPi indicate a circadian pattern and are associated with the manifestation of dystonic symptoms.

Keywords: DBS; dystonia; globus pallidus internus; local field potentials.

MeSH terms

Child
Deep Brain Stimulation*
Dystonia* / diagnosis
Dystonia* / therapy
Dystonic Disorders* / diagnosis
Dystonic Disorders* / therapy
Electrodes, Implanted
Globus Pallidus
Humans