The lipid basis of cell death and autophagy

Zhi Lin; Fei Long; Rui Kang; Daniel J Klionsky; Minghua Yang; Daolin Tang

doi:10.1080/15548627.2023.2259732

The lipid basis of cell death and autophagy

Autophagy. 2024 Mar;20(3):469-488. doi: 10.1080/15548627.2023.2259732. Epub 2023 Sep 28.

Authors

Zhi Lin^{1

2}, Fei Long^{3

4}, Rui Kang⁵, Daniel J Klionsky⁶, Minghua Yang^{1

2}, Daolin Tang⁵

Affiliations

¹ Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Hunan Clinical Research Center of Pediatric Cancer, Changsha, Hunan, China.
³ Department of Gastrointestinal Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Postdoctoral Research Station of Basic Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
⁶ Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Abstract

ACSL: acyl-CoA synthetase long chain family; DISC: death-inducing signaling complex; DAMPs: danger/damage-associated molecular patterns; Dtgn: dispersed trans-Golgi network; FAR1: fatty acyl-CoA reductase 1; GPX4: glutathione peroxidase 4; LPCAT3: lysophosphatidylcholine acyltransferase 3; LPS: lipopolysaccharide; MUFAs: monounsaturated fatty acids; MOMP: mitochondrial outer membrane permeabilization; MLKL, mixed lineage kinase domain like pseudokinase; oxPAPC: oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; OxPCs: oxidized phosphatidylcholines; PUFAs: polyunsaturated fatty acids; POR: cytochrome p450 oxidoreductase; PUFAs: polyunsaturated fatty acids; RCD: regulated cell death; RIPK1: receptor interacting serine/threonine kinase 1; SPHK1: sphingosine kinase 1; SOAT1: sterol O-acyltransferase 1; SCP2: sterol carrier protein 2; SFAs: saturated fatty acids; SLC47A1: solute carrier family 47 member 1; SCD: stearoyl-CoA desaturase; VLCFA: very long chain fatty acids.

Keywords: Apoptosis; autophagy; cell death; lipid metabolism; pathway.

Publication types

Review

MeSH terms

Apoptosis
Autophagy*
Cell Death
Fatty Acids* / metabolism
Fatty Acids, Unsaturated

Substances

Fatty Acids
Fatty Acids, Unsaturated

Grants and funding

R35 GM131919/GM/NIGMS NIH HHS/United States