The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia

Risa Miyatake; Tatsuya Fujii; Keiichi Kumasawa; Mari Ichinose; Masatake Toshimitsu; Seisuke Sayama; Takahiro Seyama; Takayuki Iriyama; Takeshi Nagamatsu; Yutaka Osuga

doi:10.1155/2023/7352947

The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia

Case Rep Obstet Gynecol. 2023 Sep 19:2023:7352947. doi: 10.1155/2023/7352947. eCollection 2023.

Authors

Affiliations

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 113-8655, Japan.
² Department of Obstetrics and Gynecology, National Center for Child Health and Development, 157-8535, Japan.
³ Department of Obstetrics and Gynecology, International University of Health and Welfare, 286-0124, Japan.

Abstract

Hyperreactio luteinalis (HL) is a rare condition that presents as bilateral ovarian enlargement during pregnancy. Typically, it is thought to be caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. The prognosis is relatively good, with many cases resulting in term birth. However, some obstetric complications, such as preeclampsia (PE) and preterm births, have been reported. We present a serious case of HL with subsequent PE that resulted in preterm delivery at 31 weeks of gestation. The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio was very high at the onset of PE at 24 weeks of gestation, followed by a modest decline, which then increased in proportion to the exacerbation of symptoms. Since HL cases have also been reported to be associated with PE, repeated measurement of the sFlt-1/PlGF ratio proved useful for better pregnancy management.

Publication types

Case Reports