Structural and Synthetic Aspects of Small Ring Oxa- and Aza-Heterocyclic Ring Systems as Antiviral Activities

Sibasish Manna; Koushik Das; Sougata Santra; Emily V Nosova; Grigory V Zyryanov; Sandipan Halder

doi:10.3390/v15091826

Structural and Synthetic Aspects of Small Ring Oxa- and Aza-Heterocyclic Ring Systems as Antiviral Activities

Viruses. 2023 Aug 28;15(9):1826. doi: 10.3390/v15091826.

Authors

Sibasish Manna¹, Koushik Das¹, Sougata Santra², Emily V Nosova^{2

3}, Grigory V Zyryanov^{2

3}, Sandipan Halder¹

Affiliations

¹ Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur 440010, India.
² Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia.
³ I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, 22 S. Kovalevskoy Street, 620219 Yekaterinburg, Russia.

Abstract

Antiviral properties of different oxa- and aza-heterocycles are identified and properly correlated with their structural features and discussed in this review article. The primary objective is to explore the activity of such ring systems as antiviral agents, as well as their synthetic routes and biological significance. Eventually, the structure-activity relationship (SAR) of the heterocyclic compounds, along with their salient characteristics are exhibited to build a suitable platform for medicinal chemists and biotechnologists. The synergistic conclusions are extremely important for the introduction of a newer tool for the future drug discovery program.

Keywords: Structure Activity Relationship (SAR); antiviral agents; heterocycles; natural products; synthetic methods.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents* / pharmacology
Drug Discovery*
Structure-Activity Relationship

Substances

Antiviral Agents

Grants and funding

Science and Engineering Research Board; ECR/2017/000966.