Sleep Disorders Associated with Neurodegenerative Diseases

Diagnostics (Basel). 2023 Sep 10;13(18):2898. doi: 10.3390/diagnostics13182898.

Abstract

Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington's disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB). This article reviews the prevalence and characteristics of sleep disorders in these conditions, highlighting their impact on patients' quality of life and disease progression. Sleep-related breathing disorders, insomnia, restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), and rapid eye movement sleep behavior disorder (RBD) are among the common sleep disturbances reported. Both pharmacological and non-pharmacological interventions play crucial roles in managing sleep disturbances and enhancing overall patient care.

Keywords: Huntington’s disease (HD); amyotrophic lateral sclerosis (ALS); hereditary ataxias; insomnia; multiple system atrophy (MSA); neurological pathologies; sleep disturbances; sleep-related breathing disorders.

Publication types

  • Review

Grants and funding

This research received no external funding.