Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases

Nina Gyorfi; Adrian Robert Gal; Andras Fincsur; Karoly Kalmar-Nagy; Kitti Mintal; Edina Hormay; Attila Miseta; Tamas Tornoczky; Anita Katalin Nemeth; Peter Bogner; Tamas Kiss; Zsuzsanna Helyes; Zoltan Sari; Mihaly Klincsik; Vladimir Tadic; Laszlo Lenard; Andras Vereczkei; Zoltan Karadi; Zoltan Vizvari; Attila Toth

doi:10.3390/biomedicines11092449

Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases

Biomedicines. 2023 Sep 3;11(9):2449. doi: 10.3390/biomedicines11092449.

Authors

Nina Gyorfi^{1

2}, Adrian Robert Gal^{1

3}, Andras Fincsur⁴, Karoly Kalmar-Nagy⁵, Kitti Mintal^{1

2}, Edina Hormay^{1

2}, Attila Miseta⁶, Tamas Tornoczky⁴, Anita Katalin Nemeth⁷, Peter Bogner⁷, Tamas Kiss⁸, Zsuzsanna Helyes^{8

9

10}, Zoltan Sari^{1

11

12}, Mihaly Klincsik^{1

11

12}, Vladimir Tadic^{11

13

14}, Laszlo Lenard^{1

2}, Andras Vereczkei⁵, Zoltan Karadi^{1

2}, Zoltan Vizvari^{1

11

14

15}, Attila Toth^{1

2}

Affiliations

¹ Medical and Engineering Multidisciplinary Cellular Bioimpedance Research Group, Szentagothai Research Centre, University of Pecs, Ifjusag Str. 20, H-7624 Pecs, Hungary.
² Institute of Physiology, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
³ Department of Medical Biology and Central Electron Microscopic Laboratory, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁴ Department of Pathology, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁵ Department of Surgery, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁶ Department of Laboratory Medicine, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁷ Department of Medical Imaging, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁸ Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary.
⁹ Eötvös Loránd Research Network, Chronic Pain Research Group, University of Pecs, H-7624 Pecs, Hungary.
¹⁰ National Laboratory for Drug Research and Development, Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
¹¹ Symbolic Methods in Material Analysis and Tomography Research Group, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 6, H-7624 Pecs, Hungary.
¹² Department of Technical Informatics, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 2, H-7624 Pecs, Hungary.
¹³ Institute of Information Technology, University of Dunaujvaros, Tancsics M. Str. 1/A, H-2401 Dunaujvaros, Hungary.
¹⁴ John von Neumann Faculty of Informatics, University of Obuda, Becsi Str. 96/B, H-1034 Budapest, Hungary.
¹⁵ Department of Environmental Engineering, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 2, H-7624 Pecs, Hungary.

Abstract

Based on a prior university patent, the authors developed a novel type of bioimpedance-based test method to noninvasively detect nonalcoholic fatty liver disease (NAFLD). The development of a new potential NAFLD diagnostic procedure may help to understand the underlying mechanisms between NAFLD and severe liver diseases with a painless and easy-to-use paraclinical examination method, including the additional function to detect even the earlier stages of liver disease. The aim of this study is to present new results and the experiences gathered in relation to NAFLD progress during animal model and human clinical trials.

Keywords: NAFLD; Wistar; bioelectrical impedance spectroscopy; clinical study; hepatic steatosis; low-frequency measurement; noninvasive measurement; validation.

Abstract

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