Model Organisms to Study Autophagy

Qiuhong Xiong; Ludwig Eichinger

doi:10.3390/cells12182212

Model Organisms to Study Autophagy

Cells. 2023 Sep 5;12(18):2212. doi: 10.3390/cells12182212.

Authors

Qiuhong Xiong¹, Ludwig Eichinger²

Affiliations

¹ Shanxi Provincial Key Laboratory of Medical Molecular Cell Biology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92 Wucheng Road, Taiyuan 030006, China.
² Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.

Abstract

Autophagy is the major lysosomal pathway for the clearance of proteins, organelles and microbes in eukaryotic cells. Therefore, autophagic dysfunction can lead to numerous human diseases, like cancer or neurodegeneration, and may facilitate infections by pathogens. However, despite tremendous advances in the understanding of autophagy over the past decades, the functions and regulations of autophagy-related proteins in canonical and non-canonical autophagy are still not fully resolved. The Special Issue "Model Organisms to Study Autophagy" organized by Cells includes six original articles and one review that show the latest achievements in autophagy research using different model organisms. The Special Issue summarizes and discusses different aspects of autophagy that open new avenues in understanding autophagy functions and mechanisms.

Keywords: autophagy; function; model organism; non-canonical autophagy.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Autophagy*
Autophagy-Related Proteins
Eukaryotic Cells*
Humans
Kinetics

Substances

Autophagy-Related Proteins

Grants and funding

This work was funded by the National Natural Science Foundation of China, grant number 82271905 and 31801972, and by the German Research Foundation, grant number CRC670, TP01.