Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission

Kevin Maringer

doi:10.1016/j.pt.2023.09.005

Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission

Trends Parasitol. 2023 Nov;39(11):898-899. doi: 10.1016/j.pt.2023.09.005. Epub 2023 Sep 25.

Author

Kevin Maringer¹

Affiliation

¹ The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK. Electronic address: kevin.maringer@pirbright.ac.uk.

PMID: 37758630
DOI: 10.1016/j.pt.2023.09.005

Abstract

With new RNA interference (RNAi) pathway-deficient mosquitoes, Merkling et al. invite a shift in our view of this pathway's role in regulating arthropod-borne virus (arbovirus) transmission. While loss of RNAi function enhanced early viral replication, little impact on transmission was observed, inviting renewed exploration of molecular barriers to arbovirus transmission.

Keywords: Aedes aegypti; RNA interference (RNAi); arbovirus; innate immunity; mosquito; transmission bottleneck.