Abiotic stress management remains under scrutiny because of the unpredictable nature of climate, which undergoes abrupt alterations. Population pressure, loss of cultivable lands, environmental pollution and other anthropogenic disturbances add to the problem and grossly hinder ongoing management strategies. This has driven increasing effort to find better performing, eco-friendly and reliable alternatives that can contribute to sustainable agricultural practices to manage abiotic stress. Nanotechnology and its implementation in agriculture have emerged as a promising option to cater to the problem of abiotic stress. Induction of reactive oxygen species (ROS) is an inevitable phenomenon linked to stress. Nanoparticles (NPs) perform dual actions in regulating ROS biology. The bidirectional roles of NPs in modulating ROS generation and/or ROS detoxification is tightly coupled within the hormetic boundaries. Nonetheless, how these NPs control the ROS metabolism within hormetic limits demands extensive investigation. This review focuses on the details of ROS metabolism under normal versus stressed conditions. It shall elaborate on the types, modes and process of uptake and translocation of NPs. The molecular dissection of the role of NPs in controlling transcriptomic expressions and modulating molecular crosstalks with other growth regulators, ions, reactive nitrogen species and other signalling molecules shall also be detailed. Throughout, this review aims to summarise the potential roles and regulation of NPs and consider how they can be used for green synthesis within a sustainable agricultural industry.