Analysis of Risk Factors for Revitrectomy in Eyes with Diabetic Vitreous Hemorrhage

Haoxin Guo; Wenbo Li; Kuan Wang; Zetong Nie; Xiang Zhang; Siqiong Bai; Naxin Duan; Xiaorong Li; Bojie Hu

doi:10.2147/DMSO.S429938

Analysis of Risk Factors for Revitrectomy in Eyes with Diabetic Vitreous Hemorrhage

Diabetes Metab Syndr Obes. 2023 Sep 19:16:2865-2874. doi: 10.2147/DMSO.S429938. eCollection 2023.

Authors

Haoxin Guo^#¹, Wenbo Li^#¹, Kuan Wang^{1

2}, Zetong Nie¹, Xiang Zhang¹, Siqiong Bai¹, Naxin Duan¹, Xiaorong Li¹, Bojie Hu¹

Affiliations

¹ Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin University Eye Hospital, Tianjin, People's Republic of China.
² Cangzhou Eye Hospital, Cangzhou, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: We aimed to investigate the risk factors associated with revitrectomy in eyes with diabetic vitreous hemorrhage and to determine the prognosis of these patients at least one year postoperatively.

Patients and methods: This retrospective case-control study had a minimum follow-up period of one year. Patients were divided into single vitrectomy group (control group, n=202) and revitrectomy group (case group, n=36) for analysis. The indications, number, and timing of revitrectomies were documented. And the revitrectomy group was further divided into two vitrectomies group (n=30) and three or more vitrectomies group (n=6). The best-corrected visual acuity (BCVA) at the last follow-up and the occurrence of neovascular glaucoma (NVG) were compared among the single vitrectomy, two vitrectomies and three or more vitrectomies groups. We conducted a thorough collection of patient data and used univariate and binary logistic regression analyses to identify the risk factors associated with revitrectomy.

Results: A total of 197 patients (238 eyes) were included. Thirty-six eyes (15.1%) required revitrectomy with six eyes (2.5%) undergoing three or more vitrectomies during the follow-up period. The median duration of the second vitrectomy was 3 (2-6) months. The indications for a second vitrectomy included 28 eyes (77.8%) of postoperative vitreous hemorrhage and 7 eyes (22.2%) combined with tractional retinal detachment. Patients undergoing three or more vitrectomies had significantly worse postoperative BCVA and a higher incidence of NVG (P<0.01). Fibrinogen> 4 g/L (P<0.001) and preoperative anti-vascular endothelial growth factor intravitreal injection (P=0.015) were independent risk factors for revitrectomy, and glycated hemoglobin A1c (HbA1c)>10% (P=0.049) showed significant difference only in univariate analysis.

Conclusion: Patients requiring revitrectomy tended to have higher fibrinogen levels, tightly adhered fibrovascular membranes, higher HbA1c levels, and worse prognoses.

Keywords: fibrinogen; proliferative diabetic retinopathy; retinal ischemia; revitrectomy; vitreous hemorrhage.

Grants and funding

Funded by Tianjin Key Medical Discipline (Specialty) Construction Project (No.TJYXZDXK-037A), Natural Science Foundation of Tianjin City (No.20JCZXJC00040), and the Science&Technology Development Fund of Tianjin Education Commission for Higher Education (No.2022ZD058).