A Potential New Use for Tocilizumab: Refractory Checkpoint Inhibitor Hepatitis

ACG Case Rep J. 2023 Sep 23;10(9):e01162. doi: 10.14309/crj.0000000000001162. eCollection 2023 Sep.

Abstract

Immune checkpoint inhibitors are becoming more commonly used for many forms of malignancy. With this class of medications being more heavily used, there has been an associated rise in medication-induced autoimmune hepatitis. This case involves a 35-year-old woman being treated with nivolumab/ipilimumab for renal cell carcinoma who developed a steroid-refractory autoimmune hepatitis.

Keywords: autoimmune hepatitis; check point inhibitor; chemotherapy; drug induced liver injury; drug-induced autoimmune hepatitis; hepatitis; ipilimumab; nivolumab; renal cell carcinoma; steroid refractory; tocilizumab.

Publication types

  • Case Reports