Two new quinolinone glycoalkaloids from Chrysanthemum indicum L. and their antimicrobial activity

Qingsong Zhu; Songhu Liu; Min Zhai; Xinrong Qiao; Qiong Chen; Nailiang Zhu

doi:10.1080/14786419.2023.2262719

Two new quinolinone glycoalkaloids from Chrysanthemum indicum L. and their antimicrobial activity

Nat Prod Res. 2023 Sep 26:1-8. doi: 10.1080/14786419.2023.2262719. Online ahead of print.

Authors

Qingsong Zhu¹, Songhu Liu¹, Min Zhai¹, Xinrong Qiao¹, Qiong Chen¹, Nailiang Zhu¹

Affiliation

¹ Xinyang Agricultural and Forestry University, Xinyang, Henan Province, China.

PMID: 37752790
DOI: 10.1080/14786419.2023.2262719

Abstract

Phytochemical investigation of Chrysanthemum indicum L. yielded two new quinolinone glycoalkaloids named as Chrysanthemumsides A-B (1-2). The structures of the new compounds were elucidated by analysis of their 1D- and 2D-NMR, HRESIMS and ECD calculations. Compounds 1-4 were evaluated for antimicrobial activity against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, and the data showed that compound 2 had significant antimicrobial effects (MIC 3.9 to 7.8 μg/mL).

Keywords: Chrysanthemum indicum L.; antimicrobial activity; compositae; quinolinone glycoalkaloids.