Non-coding RNAs' function in cancer development, diagnosis and therapy

XinYi Zhang; Xiaoqing Xu; Jiajia Song; Yumeng Xu; Hui Qian; Jianhua Jin; Zhao Feng Liang

doi:10.1016/j.biopha.2023.115527

Non-coding RNAs' function in cancer development, diagnosis and therapy

Biomed Pharmacother. 2023 Nov:167:115527. doi: 10.1016/j.biopha.2023.115527. Epub 2023 Sep 24.

Authors

XinYi Zhang¹, Xiaoqing Xu², Jiajia Song¹, Yumeng Xu¹, Hui Qian¹, Jianhua Jin³, Zhao Feng Liang⁴

Affiliations

¹ Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, Jiangsu, China; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu university, Zhenjiang, Jiangsu 212013, China.
² Nanjing Renpin ENT Hospital, Nanjing 210000, Jiangsu, China.
³ Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, Jiangsu, China. Electronic address: jianhuajin88@sina.com.
⁴ Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, Jiangsu, China; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu university, Zhenjiang, Jiangsu 212013, China. Electronic address: liangzhaofeng@ujs.edu.cn.

PMID: 37751642
DOI: 10.1016/j.biopha.2023.115527

Abstract

While previous research on cancer biology has focused on genes that code for proteins, in recent years it has been discovered that non-coding RNAs (ncRNAs)play key regulatory roles in cell biological functions. NcRNAs account for more than 95% of human transcripts and are an important entry point for the study of the mechanism of cancer development. An increasing number of studies have demonstrated that ncRNAs can act as tumor suppressor genes or oncogenes to regulate tumor development at the epigenetic level, transcriptional level, as well as post-transcriptional level. Because of the importance of ncRNAs in cancer, most clinical trials have focused on ncRNAs to explore whether ncRNAs can be used as new biomarkers or therapies. In this review, we focus on recent studies of ncRNAs including microRNAs (miRNAs), long ncRNAs (lncRNAs), circle RNAs (circRNAs), PIWI interacting RNAs (piRNAs), and tRNA in different types of cancer and explore the application of these ncRNAs in the development of cancer and the identification of relevant therapeutic targets and tumor biomarkers. Graphical abstract drawn by Fidraw.

Keywords: Cancer; Development; Diagnosis; Function; Non-coding RNA; Therapy.

Publication types

Review