Towards a potent and rapidly reversible Dexmedetomidine-based general anesthetic

PLoS One. 2023 Sep 26;18(9):e0291827. doi: 10.1371/journal.pone.0291827. eCollection 2023.

Abstract

Our results suggest that Dex supplemented with a low dose of a second agent creates a potent anesthetic that is rapidly reversed by atipamezole and caffeine.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anesthesia, General
  • Anesthetics, General*
  • Dexmedetomidine* / pharmacology

Substances

  • Dexmedetomidine
  • Anesthetics, General