cGAS-STING signaling in the tumor microenvironment

Ziqi Liu; Dan Wang; Jiarong Zhang; Pingjuan Xiang; Zhaoyang Zeng; Wei Xiong; Lei Shi

doi:10.1016/j.canlet.2023.216409

cGAS-STING signaling in the tumor microenvironment

Cancer Lett. 2023 Nov 28:577:216409. doi: 10.1016/j.canlet.2023.216409. Epub 2023 Sep 23.

Authors

Ziqi Liu¹, Dan Wang², Jiarong Zhang², Pingjuan Xiang², Zhaoyang Zeng¹, Wei Xiong³, Lei Shi⁴

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
² Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. Electronic address: xiongwei@csu.edu.cn.
⁴ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: shilei81@csu.edu.cn.

PMID: 37748723
DOI: 10.1016/j.canlet.2023.216409

Abstract

The cGAS-STING signaling is an important pathway involved in the regulation of tumor microenvironment, which affects many cellular functions including immune activation. Its role in combating tumor progression is widely recognized, especially with its function in inducing innate and adaptive immune responses, on which many immunotherapies have been developed. However, a growing number of findings also suggest a diversity of its roles in shaping tumor microenvironment, including functions that promote tumor progression. Here, we summarize the functions of the cGAS-STING signaling in tumor microenvironment to maintain tumor survival and proliferation through facilitating the forming of an immunosuppressive tumor microenvironment and discuss the current advances of STING-related immunotherapies.

Keywords: Immunotherapy; STING agonists; The cGAS-STING signaling; Tumor microenvironment; Tumor progression.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Immunity, Innate
Immunosuppressive Agents
Neoplasms* / therapy
Nucleotidyltransferases / genetics
Signal Transduction
Tumor Microenvironment*

Substances

Immunosuppressive Agents
Nucleotidyltransferases
STING1 protein, human
cGAS protein, human