Dual ionization sources high-field asymmetric waveform ion mobility spectrometry with combined ultraviolet lamp source and corona discharge source

Jiao Jin; Shan Li; Youjiang Liu; Jun Hu; Shaomin Liu; Zhen Chen; Chilai Chen

doi:10.1016/j.talanta.2023.125204

Dual ionization sources high-field asymmetric waveform ion mobility spectrometry with combined ultraviolet lamp source and corona discharge source

Talanta. 2024 Jan 15:267:125204. doi: 10.1016/j.talanta.2023.125204. Epub 2023 Sep 12.

Authors

Jiao Jin¹, Shan Li², Youjiang Liu³, Jun Hu¹, Shaomin Liu⁴, Zhen Chen¹, Chilai Chen⁵

Affiliations

¹ Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031;China; University of Science and Technology of China, Hefei, 230026, China.
² Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031;China. Electronic address: lishan@iim.ac.cn.
³ Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031;China.
⁴ Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031;China; Guangxi Key Laboratory of Intelligent Control and Maintenance of Power Equipment, School of Electrical Engineering, Guangxi University, Nanning, 530004, China.
⁵ Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031;China. Electronic address: chlchen@iim.ac.cn.

PMID: 37748271
DOI: 10.1016/j.talanta.2023.125204

Abstract

Dual ionization sources combining an ultraviolet (UV) lamp source and a corona discharge (CD) source were first used as ionization sources for high-field asymmetric waveform ion mobility spectrometry (FAIMS) to switch ionization modes without changing hardware. The CD source was manufactured using a tungsten needle and a copper ring and its usability was verified. The UV source and the CD source were combined into the FAIMS sensor and multiple ionization modes were attempted by controlling their on-off status. The optimal flow rate, quantitative and qualitative capabilities of the system were investigated, and the experiments on the impact of humidity and interferent on the system were conducted. The experimental results indicated that the flow rate of 3-4 L/min could ensure sufficient sensitivity and resolution of the system. The dual ionization sources configuration provided richer qualitative and quantitative information for FAIMS. This platform could operate in three ionization modes and had the potential to expand the analyzable compounds of UV-FAIMS. In summary, the research demonstrates that the dual ionization sources could be used as ionization sources for FAIMS, and the combined system provided convenience for chemical analysis.

Keywords: Corona discharge source; FAIMS; Ionization mode; Ionization source; Ultraviolet lamp source.