Early quantification of anti-CD19 CAR T cells by flow cytometry predicts response in R/R DLBCL

Viktoria Blumenberg; Galina Busch; Stephan Baumann; Regina Jitschin; Gloria Iacoboni; Laura Gallur; Josu Iraola-Truchuelo; Eva Hoster; Michael Winkelmann; Konstantin Hellwig; Christian Schmidt; Lisa Frölich; Benjamin Tast; Friederike Hildebrand; Kai Rejeski; Franziska Dekorsy; Christian Schmidkonz; Tobias Bäuerle; Wolfgang G Kunz; Dimitrios Mougiakakos; Fabian Müller; Michael von Bergwelt-Baildon; Pere Barba; Veit L Bücklein; Andreas Mackensen; Simon Völkl; Marion Subklewe

doi:10.1182/bloodadvances.2023010364

Early quantification of anti-CD19 CAR T cells by flow cytometry predicts response in R/R DLBCL

Blood Adv. 2023 Nov 28;7(22):6844-6849. doi: 10.1182/bloodadvances.2023010364.

Authors

Viktoria Blumenberg^{1

2

3

4}, Galina Busch², Stephan Baumann², Regina Jitschin^{5

6}, Gloria Iacoboni^{7

8}, Laura Gallur^{7

8}, Josu Iraola-Truchuelo⁷, Eva Hoster^{1

9}, Michael Winkelmann¹⁰, Konstantin Hellwig¹¹, Christian Schmidt¹, Lisa Frölich^{1

3}, Benjamin Tast², Friederike Hildebrand¹, Kai Rejeski^{1

2

3

4}, Franziska Dekorsy¹², Christian Schmidkonz^{4

13

14}, Tobias Bäuerle¹¹, Wolfgang G Kunz¹⁰, Dimitrios Mougiakakos^{5

6

15}, Fabian Müller^{5

15}, Michael von Bergwelt-Baildon^{1

3

4}, Pere Barba^{7

8}, Veit L Bücklein^{1

2

4}, Andreas Mackensen^{5

15}, Simon Völkl^{5

15}, Marion Subklewe^{1

2

3

4}

Affiliations

¹ Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
² Laboratory for Translational Cancer Immunology, LMU Gene Center, LMU Munich, Munich, Germany.
³ German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
⁴ Bavarian Center for Cancer Research (BZKF), partner site Munich, Munich, Germany.
⁵ Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany.
⁶ Department for Hematology and Oncology, Otto-von-Guericke University, Magdeburg, Germany.
⁷ Department of Hematology, Vall d'Hebron University Hospital, Experimental Hematology, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
⁸ Department of Medicine, Universitat Autònoma of Barcelona, Barcelona, Spain.
⁹ Institute for Medical Informatics, Biometry and Epidemiology, LMU Munich, Munich, Germany.
¹⁰ Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
¹¹ Department of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany.
¹² Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
¹³ Department of Nuclear Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany.
¹⁴ Institute for Medical Engineering, University of Applied Sciences Amberg-Weiden, Weiden, Germany.
¹⁵ Bavarian Cancer Research Center (BZKF), partner site Erlangen, Erlangen, Germany.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Flow Cytometry
Receptors, Antigen, T-Cell* / genetics
T-Lymphocytes*

Substances

Receptors, Antigen, T-Cell