The role of TRPV1 in RA pathogenesis: worthy of attention

Yuan Qu; Yang Fu; Yuan Liu; Chuanguo Liu; Bing Xu; Qian Zhang; Ping Jiang

doi:10.3389/fimmu.2023.1232013

The role of TRPV1 in RA pathogenesis: worthy of attention

Front Immunol. 2023 Sep 8:14:1232013. doi: 10.3389/fimmu.2023.1232013. eCollection 2023.

Authors

Yuan Qu¹, Yang Fu², Yuan Liu¹, Chuanguo Liu³, Bing Xu⁴, Qian Zhang⁵, Ping Jiang¹

Affiliations

¹ First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
² Institute of Chinese Orthopedics and Traumatology, Shandong Wendeng Osteopathic Hospital, Weihai, China.
³ Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ Department of Rheumatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
⁵ Science and Technology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Abstract

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca²⁺permeable, non-selective cation channel that is found primarily in sensory nerve fibres. Previous studies focused on pain transmission. However, recent studies have found that the TRPV1 channel, in addition to being associated with pain, also plays a role in immune regulation and their dysregulation frequently affects the development of rheumatoid arthritis (RA). A thorough understanding of the mechanism will facilitate the design of new TRPV1-targeted drugs and improve the clinical efficacy of RA. Here, we provide an updated and comprehensive overview of how the TRPV1 channel intrinsically regulates neuronal and immune cells, and how alterations in the TRPV1 channel in synoviocytes or chondrocytes extrinsically affect angiogenesis and bone destruction. Rapid progress has been made in research targeting TRPV1 for the treatment of inflammatory arthritis, but there is still much-uncharted territory regarding the therapeutic role of RA. We present a strategy for targeting the TRPV1 channel in RA therapy, summarising the difficulties and promising advances in current research, with the aim of better understanding the role of the TRPV1 channel in RA pathology, which could accelerate the development of TRPV1-targeted modulators for the design and development of more effective RA therapies.

Keywords: TRPV1; inflammation; ion channels; pain; pathogenesis; rheumatoid arthritis; treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid* / etiology
Attention
Chondrocytes
Humans
Pain
Synoviocytes*
TRPV Cation Channels

Substances

TRPV1 protein, human
TRPV Cation Channels

Grants and funding

This work was supported by the National Natural Science Foundation of China [grant number 82274481] and by the Natural Science Foundation of Shandong Province [grant number ZR2022LZY004].