Biomedical applications of artificial exosomes for intranasal drug delivery

Jinming Zhao; Jingxing Yang; Jian Jiao; Xiangdong Wang; Yan Zhao; Luo Zhang

doi:10.3389/fbioe.2023.1271489

Biomedical applications of artificial exosomes for intranasal drug delivery

Front Bioeng Biotechnol. 2023 Sep 7:11:1271489. doi: 10.3389/fbioe.2023.1271489. eCollection 2023.

Authors

Jinming Zhao^#^{1

2}, Jingxing Yang^#^{1

3}, Jian Jiao^{1

2}, Xiangdong Wang^{1

2}, Yan Zhao^{1

2}, Luo Zhang^{1

2

4

5}

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
² Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
³ Department of Otorhinolaryngology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
⁴ Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
⁵ Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.

^# Contributed equally.

Abstract

Intranasal administration offers a feasible, non-invasive method of delivering therapeutic drugs to the brain, allowing therapeutic pharmaceuticals to be administered directly to the central nervous system by bypassing the blood-brain barrier. Furthermore, exosomes are naturally occurring cell-derived nanovesicles that can serve as carriers for a variety of chemical compounds. Many studies have focused on artificial exosomes as innovative medication delivery methods. As a result, trans-nasal delivery of artificial exosomes might be employed to treat brain illnesses in a novel method. This review will outline the drug delivery mechanism of artificial extracellular vesicles, emphasize its advantages as a nasal drug carrier, particularly its application as a novel nanocarriers in brain diseases, and focus on its prospective application in chronic inflammatory nose disorders. Finally, artificial exosomes may become a unique drug delivery mode for clinical therapeutic usage.

Keywords: artificial exosomes; biomedical applications; blood-brain barrier; drug delivery; intranasal administration.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Key R&D Program of China (2022YFC2504100), the program for the Changjiang Scholars and Innovative Research Team (IRT13082), the National Natural Science Foundation of China (82000962, 82171110, and 81970852), Beijing Hospitals Authority Youth Programme (QML20230201), the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-022), Beijing Municipal Science and Technology Commission (Z211100002921057), the Capital’s funds for health improvement and research (2022-1-1091), the Beijing Natural Science Foundation (7212013 and 7222024), the Beijing New-star Plan of Science and Technology (20220484226), and the Public Welfare Development and Reform Pilot Project (2019-10).