[Circumscribed Astrocytic Gliomas]

No Shinkei Geka. 2023 Sep;51(5):884-891. doi: 10.11477/mf.1436204830.
[Article in Japanese]

Abstract

In the fifth edition central nervous system tumours volume of the WHO Classification of Tumours series, gliomas, glioneuronal tumors, and neuronal tumors are divided into six groups. The term "circumscribed" is used to refer to a relatively contained growth pattern, as compared to other inherently "diffuse" tumors. Circumscribed astrocytic gliomas include six types: pilocytic astrocytoma, high-grade astrocytoma with piloid features, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, chordoid glioma, and astroblastoma, MN1-altered. The vast majority of circumscribed astrocytic gliomas harbor genetic alterations in the mitogen-activated protein kinase pathway. Here, we review the circumscribed astrocytic gliomas, including etiology, clinical and imaging features, pathology and molecular genetics, treatment, and prognosis. This study will lead to better understanding of these newly classified tumors.

Publication types

  • English Abstract

MeSH terms

  • Astrocytoma* / genetics
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / pathology
  • Central Nervous System Neoplasms*
  • Glioma* / genetics
  • Humans
  • Neoplasms, Neuroepithelial*