Rationally designed block copolymer-based nanoarchitectures: An emerging paradigm for effective drug delivery

Rajeev Sharma; Priya Shrivastava; Laxmikant Gautam; Udita Agrawal; S Mohana Lakshmi; Suresh P Vyas

doi:10.1016/j.drudis.2023.103786

Rationally designed block copolymer-based nanoarchitectures: An emerging paradigm for effective drug delivery

Drug Discov Today. 2023 Nov;28(11):103786. doi: 10.1016/j.drudis.2023.103786. Epub 2023 Sep 22.

Authors

Rajeev Sharma¹, Priya Shrivastava², Laxmikant Gautam³, Udita Agrawal², S Mohana Lakshmi¹, Suresh P Vyas⁴

Affiliations

¹ Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, MP 474005, India.
² Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour Central University, Sagar, MP 470003, India.
³ Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour Central University, Sagar, MP 470003, India; Babulal Tarabai Institute of Pharmaceutical Science, Sagar, M.P., 470228.
⁴ Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour Central University, Sagar, MP 470003, India. Electronic address: rajeevs472@gmail.com.

PMID: 37742910
DOI: 10.1016/j.drudis.2023.103786

Abstract

Various polymeric materials have been investigated to produce unique modes of delivery for drug modules to achieve either temporal or spatial control of bioactives delivery. However, after intravenous administration, phagocytic cells quickly remove these nanostructures from the systemic circulation via the reticuloendothelial system (RES). To overcome these concerns, ecofriendly block copolymers are increasingly being investigated as innovative carriers for the delivery of bioactives. In this review, we discuss the design, fabrication techniques, and recent advances in the development of block copolymers and their applications as drug carrier systems to improve the physicochemical and pharmacological attributes of bioactives.

Keywords: bioactives; block copolymer; drug delivery; nanomedicines.

Publication types

Review

MeSH terms

Drug Carriers / chemistry
Drug Delivery Systems* / methods
Micelles
Nanostructures* / chemistry
Polymers / chemistry

Substances

Polymers
Drug Carriers
Micelles