A2AR and traumatic brain injury

Yan Zhao; Ya-Lei Ning; Yuan-Guo Zhou

doi:10.1016/bs.irn.2023.07.006

A_2AR and traumatic brain injury

Int Rev Neurobiol. 2023:170:225-265. doi: 10.1016/bs.irn.2023.07.006. Epub 2023 Aug 14.

Authors

Yan Zhao¹, Ya-Lei Ning¹, Yuan-Guo Zhou²

Affiliations

¹ Department of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, P.R. China; Institute of Brain and Intelligence, Army Medical University, Chongqing, P.R. China.
² Department of Army Occupational Disease, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery and Daping Hospital, Army Medical University, P.R. China; Institute of Brain and Intelligence, Army Medical University, Chongqing, P.R. China. Electronic address: ygzhou@tmmu.edu.cn.

PMID: 37741693
DOI: 10.1016/bs.irn.2023.07.006

Abstract

Accumulating evidence has revealed the adenosine 2A receptor is a key tuner for neuropathological and neurobehavioral changes following traumatic brain injury by experimental animal models and a few clinical trials. Here, we highlight recent data involving acute/sub-acute and chronic alterations of adenosine and adenosine 2A receptor-associated signaling in pathological conditions after trauma, with an emphasis of traumatic brain injury, including neuroinflammation, cognitive and psychiatric disorders, and other severe consequences. We expect this would lead to the development of therapeutic strategies for trauma-related disorders with novel mechanisms of action.

Keywords: Adenosine 2A receptor; Cognitive dysfunction; Neuroinflammation; Neuroprotection; Tau; Traumatic brain injury.

MeSH terms

Adenosine
Animals
Brain Injuries, Traumatic*
Humans
Mental Disorders*
Models, Animal

Substances

Adenosine