Predicting the relationship between anxiety and health-related quality of life in post-stroke patients: The role of sleep duration

Wei Liu; Xingyue Liu; Jian Wang; Shuzhi Peng; Jie Li; Mengyun Pei; Zhichao Qiu; Peng Zhang

doi:10.1016/j.jstrokecerebrovasdis.2023.107368

Predicting the relationship between anxiety and health-related quality of life in post-stroke patients: The role of sleep duration

J Stroke Cerebrovasc Dis. 2023 Nov;32(11):107368. doi: 10.1016/j.jstrokecerebrovasdis.2023.107368. Epub 2023 Sep 22.

Authors

Wei Liu¹, Xingyue Liu², Jian Wang³, Shuzhi Peng⁴, Jie Li⁵, Mengyun Pei⁴, Zhichao Qiu², Peng Zhang⁶

Affiliations

¹ General Medical Department, Lianyang Community Health Service Center, Shanghai, China.
² School of Health and Social Care, Shanghai urban construction vocational college, Shanghai, China.
³ Research and Development Department, ANEXT Shanghai Biotechnology Co., Ltd., Shanghai, China.
⁴ Graduate School, Shanghai University of Medicine & Health Sciences, Shanghai, China; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁵ School of Public Health, Anhui Medical University, Anhui, China.
⁶ School of Management, Hainan Medical University, Haikou, China; School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, China. Electronic address: zhangp@sumhs.edu.cn.

PMID: 37740992
DOI: 10.1016/j.jstrokecerebrovasdis.2023.107368

Abstract

Sleep and psychological disorders are common complaints in stroke survivors. The effectiveness of sleep duration in post-stroke on mental well-being and health outcomes has been reported recently. This study aimed to investigate the mediating effect of sleep duration on the relationship between anxiety and health-related quality of life in Chinese post-stroke; MATERIALS AND METHODS: We conducted a quantitative, cross-sectional study with participants recruited through a multistage, stratified, probability proportional to size sampling method. Anxiety, health-related quality of life, and sleep duration were measured by Zung Self-rating Anxiety Scale, World Health Organization Quality of Life Questionnaire, and a self-administered, structured questionnaire. A multiple linear regression analysis was conducted to identify the association between anxiety, sleep duration, and quality of life. The direct and indirect effects of sleep duration on health-related quality of life was assessed using the bootstrap method via Model 4 (parallel mediation) of SPSS PROCESS macro; RESULTS: A total of 856 post-stroke patients participated in the study, and incidence of anxiety symptom amongst post-stroke was 33.53%. Sleep duration mainly plays partial mediating roles in the relationship between mild-to-moderate anxiety and quality of life in physical, psychological, and environment domains, with sleep duration of 7-8h playing a major role; CONCLUSIONS: A significant relationship among anxiety, sleep duration, and quality of life in post-stroke was found in this study. The sleep duration partially mediated the association between anxiety and quality of life. Suitable prevention methods and early interventions for sleep duration may improve the quality of life for post-stroke anxiety.

Keywords: Anxiety; Mediation; Quality of life; Sleep duration; Stroke.