Microansamycins J and K from Micromonospora sp. HK160111mas13OE

Jianxiong Wang; Chunhua Lu; Yajie Tang; Yuemao Shen

doi:10.1080/14786419.2023.2261606

Microansamycins J and K from Micromonospora sp. HK160111mas13OE

Nat Prod Res. 2023 Sep 23:1-5. doi: 10.1080/14786419.2023.2261606. Online ahead of print.

Authors

Jianxiong Wang¹, Chunhua Lu¹, Yajie Tang², Yuemao Shen^{1

2}

Affiliations

¹ Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
² State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

PMID: 37740639
DOI: 10.1080/14786419.2023.2261606

Abstract

Microansamycins were novel pentaketide ansamycins isolated from Micromonospora sp. HK160111mas13OE with AHBA-C₂-C₂-C₃-C₃ skeleton and diverse post-PKS modifications. In this paper, two new congeners, namely microansamycins J (1) and K (2), were identified based on their NMR, HRESIMS data and compared with those of microansamycins F and E. Neither showed antibacterial activity against Staphy-lococcus aureus ATCC25923 and Escherichia coli at 40 µg/mL.

Keywords: Microansamycins; antibacterial activity; pentaketide ansamycin; post-PKS modification.