The benefits of rehabilitation exercise in improving chronic traumatic encephalopathy: recent advances and future perspectives

Yin-Qiong Huang; Zhe Wu; Shu Lin; Xiang-Rong Chen

doi:10.1186/s10020-023-00728-0

The benefits of rehabilitation exercise in improving chronic traumatic encephalopathy: recent advances and future perspectives

Mol Med. 2023 Sep 22;29(1):131. doi: 10.1186/s10020-023-00728-0.

Authors

Yin-Qiong Huang^#^{1

2}, Zhe Wu^#³, Shu Lin^{4

5}, Xiang-Rong Chen^{6

7}

Affiliations

¹ Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China.
² Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China.
³ Department of Neuronal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China.
⁴ Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China. shulin1956@126.com.
⁵ Group of Neuroendocrinology, Garvan Institute of Medical Research, 384 Victoria St, Sydney, Australia. shulin1956@126.com.
⁶ Department of Neuronal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China. xiangrong_chen281@126.com.
⁷ Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China. xiangrong_chen281@126.com.

^# Contributed equally.

Abstract

Traumatic encephalopathy syndrome (TES) is used to describe the clinical manifestations of chronic traumatic encephalopathy (CTE). However, effective treatment and prevention strategies are lacking. Increasing evidence has shown that rehabilitation training could prevent cognitive decline, enhance brain plasticity, and effectively improve neurological function in neurodegenerative diseases. Therefore, the mechanisms involved in the effects of rehabilitation exercise therapy on the prognosis of CTE are worth exploring. The aim of this article is to review the pathogenesis of CTE and provide a potential clinical intervention strategy for CTE.

Keywords: Chronic traumatic encephalopathy; Nerve regeneration; Neuropathology; Rehabilitation exercise; Traumatic encephalopathy syndrome.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Injuries, Traumatic*
Chronic Traumatic Encephalopathy*
Cognitive Dysfunction*
Exercise
Exercise Therapy
Humans