Linking donor-specific antibody generation with natural killer cells in antibody-mediated kidney graft rejection

Griffith B Perkins; Robert L Fairchild

doi:10.1016/j.kint.2023.07.014

Linking donor-specific antibody generation with natural killer cells in antibody-mediated kidney graft rejection

Kidney Int. 2023 Oct;104(4):644-646. doi: 10.1016/j.kint.2023.07.014.

Authors

Griffith B Perkins¹, Robert L Fairchild²

Affiliations

¹ Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Immunology Directorate, SA Pathology, Adelaide, South Australia, Australia. Electronic address: griffith.perkins@adelaide.edu.au.
² Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: fairchr@ccf.org.

PMID: 37739612
DOI: 10.1016/j.kint.2023.07.014

Abstract

Natural killer (NK) cell infiltration of kidney allografts is a distinguishing feature of antibody-mediated rejection. Bailly et al. identify a distinct population of cytotoxic CD160⁺ interleukin-21 receptor⁺ CD56^dimCD16^bright NK cells that are uniquely found in the peripheral blood of donor-specific antibody-positive kidney transplant recipients and are present in kidney allografts with active antibody-mediated rejection. This population is implicated in a T follicular helper/interleukin-21/NK cell axis that links donor-specific antibody generation with graft-infiltrating NK cells in antibody-mediated rejection.

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MeSH terms

Antibodies*
Graft Rejection* / prevention & control
Humans
Kidney
Killer Cells, Natural
Tissue Donors

Substances

Antibodies