Biotransformation research advances - 2022 year in review

S Cyrus Khojasteh; Upendra A Argikar; Lionel Cheruzel; Sungjoon Cho; Rachel D Crouch; Deepika Dhaware; Carley J S Heck; Kevin M Johnson; Amit S Kalgutkar; Lloyd King; Joyce Liu; Bin Ma; Hlaing Maw; Grover P Miller; Herana Kamal Seneviratne; Ryan H Takahashi; Shuai Wang; Cong Wei; Klarissa D Jackson

doi:10.1080/03602532.2023.2262161

Biotransformation research advances - 2022 year in review

Drug Metab Rev. 2023 Nov;55(4):301-342. doi: 10.1080/03602532.2023.2262161. Epub 2023 Oct 28.

Authors

S Cyrus Khojasteh¹, Upendra A Argikar², Lionel Cheruzel¹, Sungjoon Cho¹, Rachel D Crouch³, Deepika Dhaware⁴, Carley J S Heck⁵, Kevin M Johnson⁶, Amit S Kalgutkar⁷, Lloyd King⁸, Joyce Liu¹, Bin Ma¹, Hlaing Maw⁹, Grover P Miller¹⁰, Herana Kamal Seneviratne¹¹, Ryan H Takahashi¹², Shuai Wang¹, Cong Wei¹³, Klarissa D Jackson¹⁴

Affiliations

¹ Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
² Non-clinical Development, Bill and Melinda Gates Medical Research Institute, Cambridge, MA, USA.
³ Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, TN, USA.
⁴ DMPK and Safety Sciences, Orion Pharma, Espoo, Finland.
⁵ Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USA.
⁶ Drug Metabolism and Pharmacokinetics, Inotiv, MD Heights, MO, USA.
⁷ Medicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.
⁸ Quantitative Drug Discovery, UCB Biopharma UK, Slough UK.
⁹ Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA.
¹⁰ Department of Biochemistry and Molecular Biology, University of AR for Medical Sciences, Little Rock, AR, USA.
¹¹ Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA.
¹² Drug Metabolism and Pharmacokinetics, Denali Therapeutics, South San Francisco, CA, USA.
¹³ Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA.
¹⁴ Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.

PMID: 37737116
DOI: 10.1080/03602532.2023.2262161

Abstract

This annual review is the eighth of its kind since 2016 (Baillie et al. 2016, Khojasteh et al. 2017, Khojasteh et al. 2018, Khojasteh et al. 2019, Khojasteh et al. 2020, Khojasteh et al. 2021, Khojasteh et al. 2022). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation.

Keywords: Drug metabolism; P450; biotransformation; mechanism; microbiome.

Publication types

Review

MeSH terms

Biotransformation*
Humans

Grants and funding

R35 GM143044/GM/NIGMS NIH HHS/United States