The role of programmed cell death in diabetic foot ulcers

Juncheng Li; Chengli Jiang; Jian Xia

doi:10.1111/iwj.14399

The role of programmed cell death in diabetic foot ulcers

Int Wound J. 2023 Sep 22;21(2):e14399. doi: 10.1111/iwj.14399. Online ahead of print.

Authors

Juncheng Li^{1

2}, Chengli Jiang^{1

2}, Jian Xia^{1

2}

Affiliations

¹ Department of Orthopedics, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, China.
² Medical Department of Graduate School, Nanchang University, Nanchang, China.

Abstract

Diabetic foot ulcer, is a chronic complication afflicting individuals with diabetes, continue to increase worldwide, immensely burdening society. Programmed cell death, which includes apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis, has been increasingly implicated in the pathogenesis of diabetic foot ulcer. This review is based on an exhaustive examination of the literature on 'programmed cell death' and 'diabetic foot ulcers' via PubMed. The findings revealed that natural bioactive compounds, noncoding RNAs and certain proteins play crucial roles in the healing of diabetic foot ulcers through various forms of programmed cell death, including apoptosis, autophagy, ferroptosis and pyroptosis.

Keywords: diabetic foot ulcers; natural active ingredients; noncoding RNAs; programmed cell death; protein.

Publication types

Review