An innate immune sensor wandering around - NOD1 promotes cell migration via non-canonical signaling

FEBS J. 2023 Nov;290(22):5292-5294. doi: 10.1111/febs.16952. Epub 2023 Sep 21.

Abstract

NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcription factor NF-κB. Next to its role in pathogen recognition, NOD1 has been associated with cancer progression. In this regard, Hezinger et al. investigated a non-canonical role of NOD1 in cell migration. They discovered that NOD1 is crucial for the migration and chemotaxis of HeLa cells and identified HAX-1 as a novel interaction partner.

Keywords: Nod-like receptors; cell migration; innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Movement
  • HeLa Cells
  • Humans
  • Immunity, Innate
  • NF-kappa B* / genetics
  • NF-kappa B* / metabolism
  • Nod1 Signaling Adaptor Protein / genetics
  • Nod1 Signaling Adaptor Protein / metabolism
  • Signal Transduction*

Substances

  • NF-kappa B
  • NOD1 protein, human
  • Nod1 Signaling Adaptor Protein