The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Cristian A Hernandez; Eliseo A Eugenin

doi:10.1016/j.coph.2023.102404

The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Curr Opin Pharmacol. 2023 Dec:73:102404. doi: 10.1016/j.coph.2023.102404. Epub 2023 Sep 19.

Authors

Cristian A Hernandez¹, Eliseo A Eugenin²

Affiliations

¹ Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
² Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA. Electronic address: eleugeni@utmb.edu.

PMID: 37734241
PMCID: PMC10838406 (available on 2024-12-01)
DOI: 10.1016/j.coph.2023.102404

Abstract

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

Keywords: ATP; COVID-19; Connexin; Gap junctions; Hemichannels; NeuroHIV.

Publication types

Review

MeSH terms

Adenosine Triphosphate / metabolism
COVID-19*
Connexins
HIV Infections* / drug therapy
Humans
Receptors, Purinergic / metabolism
SARS-CoV-2

Substances

Connexins
Receptors, Purinergic
Adenosine Triphosphate

Abstract

Publication types

MeSH terms

Substances

Grants and funding