miRNA contributes to neuropathic pains

Reyhaneh Vali; Ali Azadi; Ashkan Tizno; Tahereh Farkhondeh; Fariborz Samini; Saeed Samarghandian

doi:10.1016/j.ijbiomac.2023.126893

miRNA contributes to neuropathic pains

Int J Biol Macromol. 2023 Dec 31;253(Pt 4):126893. doi: 10.1016/j.ijbiomac.2023.126893. Epub 2023 Sep 18.

Authors

Reyhaneh Vali¹, Ali Azadi², Ashkan Tizno³, Tahereh Farkhondeh⁴, Fariborz Samini⁵, Saeed Samarghandian⁶

Affiliations

¹ Department of Biology, Faculty of Modern Science, Tehran Medical Branch, Islamic Azad University, Tehran, Iran; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
² Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Neuroscience Research Center, Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
⁶ Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran. Electronic address: samarghandians1@nums.ac.ir.

PMID: 37730007
DOI: 10.1016/j.ijbiomac.2023.126893

Abstract

Neuropathic pain (NP) is a kind of chronic pain caused by direct injury to the peripheral or central nervous system (CNS). microRNAs (miRNAs) are small noncoding RNAs that mostly interact with the 3 untranslated region of messenger RNAs (mRNAs) to regulate the expression of multiple genes. NP is characterized by changes in the expression of receptors and mediators, and there is evidence that miRNAs may contribute to some of these alterations. In this review, we aimed to fully comprehend the connection between NP and miRNA; and also, to establish a link between neurology, biology, and dentistry. Studies have shown that targeting miRNAs may be an effective therapeutic strategy for the treatment of chronic pain and potential target for the prevention of NP.

Keywords: Chronic pain; Inflammation; MicroRNA; NP; Neuralgia; Neuropathy.

Publication types

Review

MeSH terms

Chronic Pain*
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Neuralgia* / genetics
Neuralgia* / metabolism

Substances

MicroRNAs