Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism

Junpeng Sun; Xiaobang Liu; Jiaqun Du; Jinyu An; Yingqiao Li; Yu Hu; Shuai Cheng; Ying Xiong; Yanan Yu; He Tian; Xifan Mei; Chao Wu

doi:10.1016/j.ijbiomac.2023.126999

Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism

Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126999. doi: 10.1016/j.ijbiomac.2023.126999. Epub 2023 Sep 18.

Authors

Junpeng Sun¹, Xiaobang Liu¹, Jiaqun Du¹, Jinyu An¹, Yingqiao Li¹, Yu Hu², Shuai Cheng³, Ying Xiong⁴, Yanan Yu⁵, He Tian⁶, Xifan Mei⁷, Chao Wu⁸

Affiliations

¹ Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China.
² Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, China.
³ Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, China. Electronic address: cscs@stu.jzmu.edu.cn.
⁴ Normandie Université, ENSICAEN, UNICAEN, CNRS, Laboratoire Catalyse et Spectrochimie (LCS), 14050 Caen, France. Electronic address: ying.xiong@ensicaen.fr.
⁵ Medical College of Jinzhou Medical University, Jinzhou Medical University, 121010, China.
⁶ Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, China. Electronic address: tianhe@jzmu.edu.cn.
⁷ Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, China; Key Laboratory of Medical Tissue Engineering of Liaoning Province, Jinzhou Medical University, Jinzhou, Liaoning 121001, China. Electronic address: meixifan@jzmu.edu.cn.
⁸ Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning 121001, China; Key Laboratory of Medical Tissue Engineering of Liaoning Province, Jinzhou Medical University, Jinzhou, Liaoning 121001, China. Electronic address: wuchao@jzmu.edu.cn.

PMID: 37730000
DOI: 10.1016/j.ijbiomac.2023.126999

Abstract

In this study, manganese-doped albumin-gelatin composite nanogels (MAGN) were prepared and used to load berberine (Ber) for the treatment of gouty arthritis (GA). The nanodrug delivery system (Ber-MAGN) can target inflammatory joints due to the intrinsic high affinity of albumin for SPARC, which is overexpressed at the inflammatory site of GA. Characterization of the pharmaceutical properties in vitro showed that Ber-MAGN had good dispersion, and the particle size was 121 ± 10.7 nm. The sustained release effect significantly improved the bioavailability of berberine. In vitro and in vivo experimental results showed that Ber-MAGN has better therapeutic effects in relieving oxidative stress and suppressing inflammation. Therefore, Ber-MAGN, as a potential pharmaceutical preparation for GA, provides a new reference for the clinical treatment plan of GA.

Keywords: Berberine; Gout arthritis; Nanodrug delivery system.

MeSH terms

Animals
Arthritis, Gouty* / drug therapy
Berberine* / pharmacology
Gelatin
Manganese
Nanogels / therapeutic use
Rats

Substances

Berberine
Gelatin
Manganese
polyethylene glycol polyethyleneimine nanogel
Nanogels