The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

Jia-Hua Feng; Kang Chen; Si-Yu Shen; Yun-Feng Luo; Xi-Hong Liu; Xin Chen; Wei Gao; Yu-Ru Tong

doi:10.1016/j.biopha.2023.115511

The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

Biomed Pharmacother. 2023 Nov:167:115511. doi: 10.1016/j.biopha.2023.115511. Epub 2023 Sep 18.

Authors

Jia-Hua Feng¹, Kang Chen², Si-Yu Shen³, Yun-Feng Luo³, Xi-Hong Liu⁴, Xin Chen⁵, Wei Gao³, Yu-Ru Tong⁶

Affiliations

¹ School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
² National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
³ School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
⁴ School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
⁵ School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
⁶ School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. Electronic address: tongyuru@ccmu.edu.cn.

PMID: 37729733
DOI: 10.1016/j.biopha.2023.115511

Abstract

Corydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components and can be characterized into protoberberine alkaloids, aporphine alkaloids, opiate alkaloids and others and proper extraction or co-administration methods modulate their contents and efficacy. Alkaloids from C. yanhusuo have various pharmacological effects on the nervous system, cardiovascular system, cancer and others through multiple molecular mechanisms such as modulating neurotransmitters, ion channels, gut microbiota, HPA axis and signaling pathways and are potential treatments for many diseases. Plenty of novel drug delivery methods such as autologous red blood cells, self-microemulsifying drug delivery systems, nanoparticles and others have also been investigated to better exert the effects of alkaloids from C. yanhusuo. This review summarized the alkaloid components of C. yanhusuo, their pharmacological effects and mechanisms, and methods of drug delivery to lay a foundation for future investigations.

Keywords: Alkaloids; Corydalis yanhusuo; Papaveraceae; Pharmacological effects; Tetrahydropalmatine (PubChem CID: 72301); Traditional Chinese medicine; berberine (PubChem CID: 2353); columbamine (PubChem CID: 72310); coptisine (PubChem CID: 72322); corydaline (PubChem CID: 101301); dehydrocorydaline (PubChem CID: 34781); glaucine (PubChem CID: 16754); jatrorrhizine (PubChem CID: 72323); palmatine (PubChem CID: 19009); protopine (PubChem CID: 4970).

Publication types

Review