[68Ga]Ga‑LNC1007 PET/CT in the evaluation of renal cell carcinoma: comparison with 2-[18F]FDG/[68Ga]Ga-PSMA PET/CT

Rong Lin; Chao Wang; Shaohao Chen; Tingting Lin; Hai Cai; Shaoming Chen; Yun Yang; Jiaying Zhang; Fuqi Xu; Jingjing Zhang; Xiaoyuan Chen; Jie Zang; Weibing Miao

doi:10.1007/s00259-023-06436-5

[⁶⁸Ga]Ga‑LNC1007 PET/CT in the evaluation of renal cell carcinoma: comparison with 2-[¹⁸F]FDG/[⁶⁸Ga]Ga-PSMA PET/CT

Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):535-547. doi: 10.1007/s00259-023-06436-5. Epub 2023 Sep 20.

Authors

Rong Lin^#^{1

2}, Chao Wang^#^{1

2}, Shaohao Chen³, Tingting Lin³, Hai Cai³, Shaoming Chen^{1

2}, Yun Yang^{1

2}, Jiaying Zhang^{1

2}, Fuqi Xu^{1

2}, Jingjing Zhang^{4

5

6}, Xiaoyuan Chen^{7

8

9

10}, Jie Zang^{11

12}, Weibing Miao^{13

14

15}

Affiliations

¹ Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.
² Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Changle District, No. 999 Huashan Road, Fuzhou, 350212, China.
³ Department of Urology, Urology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
⁴ Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. j.zhang@nus.edu.sg.
⁵ Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. j.zhang@nus.edu.sg.
⁶ Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. j.zhang@nus.edu.sg.
⁷ Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. chen.shawn@nus.edu.sg.
⁸ Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. chen.shawn@nus.edu.sg.
⁹ Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. chen.shawn@nus.edu.sg.
¹⁰ Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore. chen.shawn@nus.edu.sg.
¹¹ Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China. 15901495106@163.com.
¹² Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Changle District, No. 999 Huashan Road, Fuzhou, 350212, China. 15901495106@163.com.
¹³ Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China. miaoweibing@126.com.
¹⁴ Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Changle District, No. 999 Huashan Road, Fuzhou, 350212, China. miaoweibing@126.com.
¹⁵ Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China. miaoweibing@126.com.

^# Contributed equally.

PMID: 37728667
DOI: 10.1007/s00259-023-06436-5

Abstract

Purpose: To compare the potential efficiency of [⁶⁸Ga]Ga-LNC1007 with 2-[¹⁸F]FDG/[⁶⁸Ga]Ga-PSMA PET/CT for detecting renal cell carcinoma (RCC) and to explore parameters derived from [⁶⁸Ga]Ga-LNC1007 PET/CT for discriminating pathological characteristics in RCC.

Methods: Twenty-five RCC patients confirmed by pathology were enrolled in this prospective study. The maximum standardized uptake value (SUV_max), mean SUV (SUV_mean), gross tumor volume (GTV) and total lesion-tracer (TL-tracer) of lesions were calculated from the corresponding PET/CT images. Pathological characteristics included World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade and adverse pathological features (tumor necrosis or sarcomatoid or rhabdoid feature).

Results: [⁶⁸Ga]Ga-LNC1007 PET/CT showed a higher detection rate for primary lesions than 2-[¹⁸F]FDG and [⁶⁸Ga]Ga-PSMA (LNC1007 vs. FDG: 13/17 vs. 4/17, P = 0.005; LNC1007 vs. PSMA: 9/11 vs. 6/11, P = 0.361). [⁶⁸Ga]Ga-LNC1007 PET/CT showed higher SUV_max (6.6 vs. 3.7, P = 0.005), SUV_mean (4.1 vs. 2.3, P = 0.001) and TBR (2.6 vs. 1.7, P = 0.011) compared with 2-[¹⁸F]FDG PET/CT, and it also showed higher TBR (2.9 vs. 0.5, P = 0.003), TBR-delay (2.8 vs. 0.3, P = 0.003), GTV (84.1 vs. 42.9, P = 0.003) and TL-tracer (442.7 vs. 235.8, P = 0.008) compared with [⁶⁸Ga]Ga-PSMA PET/CT. SUV_max and TBR derived from [⁶⁸Ga]Ga-LNC1007 PET/CT could effectively differentiate WHO/ISUP grade (3-4 vs. 1-2) and adverse pathological features (positive vs. negative) (SUV_max: AUC 0.81, P = 0.04; AUC 0.80, P = 0.033; TBR: AUC 0.84, P = 0.026; AUC 0.85, P = 0.014). The SUV_max was positively correlated with the FAP expression, integrin α_vβ₃ expression and the total expression of FAP and integrin α_vβ₃ (r = 0.577, P = 0.006, r = 0.701, P < 0.001, and r = 0.702, P < 0.001, respectively).

Conclusion: [⁶⁸Ga]Ga-LNC1007 is a promising tracer for RCC imaging and can effectively identify aggressive pathological characteristics of RCC.

Keywords: Fibroblast activation protein; Integrin αvβ3; Renal cell carcinoma; [68Ga]Ga-PSMA; [68Ga]Ga-LNC1007.

MeSH terms

Carcinoma, Renal Cell* / diagnostic imaging
Fluorodeoxyglucose F18
Gallium Radioisotopes
Humans
Integrins
Kidney Neoplasms* / diagnostic imaging
Oligopeptides
Positron Emission Tomography Computed Tomography / methods
Prospective Studies

Substances

Gallium Radioisotopes
Fluorodeoxyglucose F18
Oligopeptides
Integrins

Abstract

MeSH terms

Substances

Grants and funding